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科研人员

科研人员

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马坤,中国科学院合肥物质科学研究院副研究员,1985年11月出生。2017年于中国科学院大学获生物物理学博士学位,同年进入中国科学院强磁场科学中心从事博士后研究(2017—2020年),出站后留中心工作,历任助理研究员、副研究员。其研究依托强磁场大科学平台,围绕"趋磁细菌仿生矿化—磁性纳米材料可控合成—疾病诊疗一体化"这一主线展开,贯通了从生物矿化分子机制,到磁性纳米材料创制,再到肿瘤与肝脏疾病精准诊疗的完整研究链条。迄今以通讯/第一作者(含共同)发表论文40篇,成果见于 PNAS、ACS Nano、Advanced Science、Nano Letters、Angewandte Chemie、Analytical Chemistry、Chemical Engineering Journal、Cell Reports、ACS Applied Materials & Interfaces、Applied and Environmental Microbiology 等国际期刊,获国家发明专利1项。作为项目负责人,主持国家自然科学基金青年科学基金项目、国家重点实验室基金项目、安徽省自然科学基金面上项目及安徽省转化医学研究院科研基金项目各1项。现任 Frontiers in Microbiology 特邀副主编。研究工作方向。其一,趋磁细菌生物矿化与磁性纳米材料的仿生可控合成:深入解析趋磁细菌生物矿化机制,将仿生矿化与高磁场精准调控相结合,建立了一套利用生物矿化蛋白、磁场强度与磁场梯度协同调控磁性纳米颗粒尺寸与形貌的成熟方法,并创新性提出磁场梯度调控纳米反应器的动力学机制,为高性能磁性诊疗探针的定制化制备奠定基础。其二,磁性纳米探针的多模态成像与诊疗一体化:将上述自主合成的磁性纳米材料应用于肿瘤、肝纤维化、肝癌等重大疾病的精准诊疗——在诊断端,依托自主搭建的14.1T磁共振体内成像系统、实时生命检测系统及¹H/¹⁹F/CEST多模态成像平台,实现肝纤维化等病变的早期、高灵敏影像学检测与肿瘤病灶的精准定位;在治疗端,以磁性纳米颗粒为核心载体开发靶向药物递送系统,并联合磁靶向影像引导治疗等手段,构建集早期诊断、靶向递送与高效治疗于一体的诊疗体系。 

联系方式: makun@hmfl.ac.cn 

代表性论文:

1. Ma, Kun, et al. "Magnetosome-inspired synthesis of soft ferrimagnetic nanoparticles for magnetic tumor targeting." Proceedings of the National Academy of Sciences 119.45 (2022): e2211228119.

2. Tao, Tongxiang, Ma, Kun*,et al. "Boosting SARS-CoV-2 enrichment with ultrasmall immunomagnetic beads featuring superior magnetic moment." Analytical Chemistry 95.30 (2023): 11542-11549.

3. Xu, Shuai, Ma, Kun*,et al. "In situ one-pot synthesis of Fe2O3@ BSA core-shell nanoparticles as enhanced T1-weighted magnetic resonance imagine contrast agents." ACS applied materials & interfaces 12.51 (2020): 56701-56711.

4. Wan, Juan, Ma, Kun,et al. "Biomineralization in magnetotactic bacteria: From diversity to molecular discovery-based applications." Cell Reports 43.12 (2024).

5. Li, Zehua, Ma, Kun*,et al. "Efficient and Specific PDGFRβ‐Targeting Dual‐Mode T1‐T2 MRI Nanoprobe for Early Diagnosis of Non‐Alcoholic Fatty Liver." Advanced Science 12.23 (2025): 2413788.

6. Ji, Sihan, Ma, Kun*,et al. "Pt Colloidosomes with Broadband Absorption for Near‐Infrared Light Photocatalysis Through D‐Band Hot‐Carriers Generation." Angewandte Chemie 137.39 (2025): e202509431.

7. Zhao, Xianglong, Ma, Kun*,et al. "BSA-magnetite nanotorpedo for safe and efficient delivery of chemotherapy drugs." Chemical Engineering Journal 454 (2023): 140440.

8. Rehman, Sajid Ur, Ma, Kun*,et al. "Hydrophilic Metal–Organic Frameworks Regulated by Biomineralized Protein for Enhanced Stability and Drug Delivery." Nano Letters 24.49 (2024): 15652-15661.

9. Xia, Haining, Ma, Kun*, et al. "Heat sensitive E-helix cut ferritin nanocages for facile and high-efficiency loading of doxorubicin." International Journal of Biological Macromolecules 253 (2023): 126973.

10. Zhang, Jing, Ma, Kun*,et al. "Influence of a 7 T magnetic field on growth, biomineralization, and denitrification metabolism in Magnetospirillum gryphiswaldense MSR-1." Applied and Environmental Microbiology 91.10 (2025): e01069-25.

 


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