从事蛋白质结构、功能和理性设计的基础研究，致力于从蛋白质结构生物学出发，特别是利用核磁共振技术在蛋白质动力学和构象动态变化研究中的优势，结合分子、生化、细胞生物学技术的使用，开展针对生物技术工具蛋白和蛋白质药物的改造、理性设计以及应用的开发。
主要研究方向为
1、光敏蛋白的作用机制、光遗传学工具的开发与应用。
2、重大疾病相关外周膜蛋白与生物膜相互作用机制。
3、蛋白质药物、酶的蛋白质工程改造和应用。
5篇代表作
Chanjuan Wan#, Lei Zhu#, Simin Wang, Xueqing Zhan1, Jun Zhao, Xiaozhan Qu & Chengdong Huang*, Distinct Phosphorylation Mechanisms as Dynamic Switches for Hsp90 Regulation, Nature Communications, 2026, in press.
Changhao Wang; Yunyan Li; Yanqin Lin; Yonghua Wang*; Zhong Chen*; Lei Zhu*; Junfeng Wang*; In situ enzymatic hydrolysis characterisation of phospholipid using H-1 NMR in a heterogeneous environment, LWT - Food Science and Technology, 2023, 10: 114592
He, Lian#; Tan, Peng#; Zhu, Lei#; Huang, Kai; Nguyen, Nhung T; Wang, Rui; Guo, Lei; Li, Ling; Yang, Yuhan; Huang, Zixian; Huang, Yun*; Han, Gang*; Wang, Junfeng*; Zhou, Yubin*; Circularly permuted LOV2 as a modular photoswitch for optogenetic engineering., Nature Chemical Biology, 2021, 17(8): 915-923
Zhu, Lei#; Zhao, Hongxin#; Liu, Juanjuan#; Cai, Hao; Wu, Bo; Liu, Zhijun; Zhou, Shu; Liu, Qingsong; Li, Xiaokun; Bao, Bin; Liu, Jian; Dai, Han*; Wang, Junfeng*; Dynamic folding modulation generates FGF21 variant against diabetes., EMBO Reports, 2020, 22(1): 0-e51352
He, Lian#; Jing, Ji#; Zhu, Lei#; Tan, Peng; Ma, Guolin; Zhang, Qian; Nhung T. Nguyen; Wang, Junfeng*; Zhou, Yubin*; Huang, Yun*; Optical control of membrane tethering and interorganellar communication at nanoscales, Chemical Science, 2017, 8(8): 5275-5281 (封面文章)
所有一作通讯
Chanjuan Wan#, Lei Zhu#, Simin Wang, Xueqing Zhan1, Jun Zhao, Xiaozhan Qu & Chengdong Huang*, Distinct Phosphorylation Mechanisms as Dynamic Switches for Hsp90 Regulation, Nature Communications, 2026, in press.
Lina Zhu; Runhan Wang; Mingyang Jin; Yingkui Dong; Hongxin Zhao; Junfeng Wang*; Lei Zhu*; Structural insights into photo-state-specific binding of affibody Aff6 to the photosensory core module of DrBphP, Journal of Photochemistry and Photobiology B: Biology, 2026, 278:113431
Runhan Wang, Lina Zhu, Junfeng Wang*, and Lei Zhu*, Backbone resonance assignments of PhoCl, a photocleavable protein. Biomol NMR Assign, 2025. 19(1): p. 41-45.
Ziwei Wu; Ling Li; Lina Zhu; Runhan Wang; Yingkui Dong; Yaoyao Zhang; Yujuan Wang*; Junfeng Wang*; Lei Zhu*; Structural determinants for membrane binding of the EGFR juxtamembrane domain, FEBS Letters, 2024, 598(11): 1402-1410
Changhao Wang; Yunyan Li; Yanqin Lin; Yonghua Wang*; Zhong Chen*; Lei Zhu*; Junfeng Wang*; In situ enzymatic hydrolysis characterisation of phospholipid using H-1 NMR in a heterogeneous environment, LWT - Food Science and Technology, 2023, 10: 114592
Lina Zhu; Hongxin Zhao; Yizhuo Wang; Chuandi Yu; Juanjuan Liu; Ling Li; Zehua Li; Jin Zhang; Han Dai; Junfeng Wang*; Lei Zhu*; Solubilization, purification, and ligand binding characterization of G protein-coupled receptor SMO in native membrane bilayer using styrene maleic acid copolymer, PeerJ, 2022, 10: e13381
He, Lian#; Tan, Peng#; Zhu, Lei#; Huang, Kai; Nguyen, Nhung T; Wang, Rui; Guo, Lei; Li, Ling; Yang, Yuhan; Huang, Zixian; Huang, Yun*; Han, Gang*; Wang, Junfeng*; Zhou, Yubin*; Circularly permuted LOV2 as a modular photoswitch for optogenetic engineering., Nature Chemical Biology, 2021, 17(8): 915-923
Li, Ling; He, Lian; Wu, Bo; Yu, Chuandi; Zhao, Hongxin; Zhou, Yubin; Wang, Junfeng*; Zhu, Lei*; Structural Determinants for Light-Dependent Membrane Binding of a Photoswitchable Polybasic Domain., ACS Synthetic Biology, 2021, 10(3): 542-551
Zhu, Lei#; Zhao, Hongxin#; Liu, Juanjuan#; Cai, Hao; Wu, Bo; Liu, Zhijun; Zhou, Shu; Liu, Qingsong; Li, Xiaokun; Bao, Bin; Liu, Jian; Dai, Han*; Wang, Junfeng*; Dynamic folding modulation generates FGF21 variant against diabetes., EMBO Reports, 2020, 22(1): 0-e51352
He, Lian#; Jing, Ji#; Zhu, Lei#; Tan, Peng; Ma, Guolin; Zhang, Qian; Nhung T. Nguyen; Wang, Junfeng*; Zhou, Yubin*; Huang, Yun*; Optical control of membrane tethering and interorganellar communication at nanoscales, Chemical Science, 2017, 8(8): 5275-5281 (封面文章)
Lei Zhu; Jing Yang; Hua Li; Hongbin Sun; Jinsong Liu; Junfeng Wang*; Conformational change study of dengue virus NS2B-NS3 protease using 19F NMR spectroscopy, Biochemical and Biophysical Research Communications, 2015, 461(4): 677-680