本人主要从事蛋白质工程改造相关研究，聚焦于以受体嵌合式抗体为骨架，体外构建功能性抗体药物，实现对肿瘤细胞的精准靶向杀伤。通过将受体-抗体嵌合策略与蛋白质人工设计相结合，赋予抗体分子多重识别与信号调节功能，显著提升肿瘤靶向的特异性和抗肿瘤免疫效能。利用分子模拟与定向进化技术，系统优化嵌合抗体的亲和力、稳定性及效应功能，构建系列具有双靶向的功能性抗体候选分子，建立高效的体外筛选与功能验证平台。
1. Yizhuo Wang; Hengfang Tang; Jiarui Li; Wanxue Wang; Ming Li; Chenchen Zhu; Han Dai; Hongxin Zhao; Lubin Jiang; Bo Wu; Junfeng Wang. A strategy for the development of receptorcontaining antibodies targeting malaria variant surface antigens. Science China Life Sciences, 2025, 68(10): 3114-3116.
2. Hao Wang; Xiaohui Zhang; Cunlong Yin; Lu Liu; Liang Chen; Hengfang Tang; Bo Wu; Junfeng Wang. High-purity preparation and biophysical characterization of OX40-TC in lipid nanodiscs. Protein Expression and Purification, 2025, 230(106697).
3. Hengfang Tang; Zhu Zhu; Zhiming Zheng; Han Wang; Chu Li; Li Wang; Genhai Zhao; Peng Wang. A study of hydrophobins-modified menaquinone-7 on osteoblastic cells differentiation. Molecular and Cellular Biochemistry, 2021, 476(4): 1939-1948.