中国科学院合肥物质科学研究院强磁场科学中心坐落于安徽省合肥市风景秀丽的科学岛，2008年4月30日经中国科学院批准成立，依托中国科学院合肥物质科学研究院管理（科发人教字〔2008〕133号），其前身是2005年12月20日成立的“合肥强磁场科学技术研究中心”。中心目标：发展强磁... 更多简介 +
稳态强磁场实验装置（Steady High Magnetic Field Facility，简称SHMFF）是国家发改委支持的“十一五”国家重大科技基础设施。SHMFF法人单位是中国科学院合肥物质科学研究院，共建单位是中国科学技术大学。各项任务以中国科学院强磁场科学中心为依托完成... 更多简介 +
报告人：Haribabu Arthanari , PH,D
邀请人：王俊峰 研究员
时 间： 2015.06.03（周三） 下午3:00
地 点： 强磁场中心 201会议室
简 介：Haribabu Arthanari, PH,D, Biological Chemistry & Molecular Pharmacology, Harvard Medical School, Boston.
Protein-Protein Interactions (PPIs) is the holy grail of therapeutic intervention, offering a plethora of distinct structural landscapes as potential targets. Nuclear Magnetic Resonance (NMR) Spectroscopy is unique tool to study these interactions, especially the weak yet critical associations.The talk will detail unpublished studies on characterizing, validating and targeting three different PPIs with implications in fatty acid/cholesterol synthesis, multiple drug resistance in fungi, and nuclear egress in herpesviruses. The unparalled and synergistic nature of NMR in addition to novel NMR methods for use in structural characterization and drug discovery will also be presented.
selected publications:
1. Brazin KN, Mallis RJ, Li C, Keskin DB, Arthanari H, Gao Y, Wu SL, Karger BL, Wagner G, Reinherz EL. Constitutively oxidized CXXC motifs within the CD3 heterodimeric ectodomains of the T cell receptor complex enforce the conformation of juxtaposed segments. J Biol Chem. 2015 Jan 2; 290(1):239.
2. Papadopoulos E, Jenni S, Kabha E, Takrouri KJ, Yi T, Salvi N, Luna RE, Gavathiotis E, Mahalingam P, Arthanari H, Rodriguez-Mias R, Yefidoff-Freedman R, Aktas BH, Chorev M, Halperin JA, Wagner G. Structure of the eukaryotic translation initiation factor eIF4E in complex with 4EGI-1 reveals an allosteric mechanism for dissociating eIF4G. Proc Natl Acad Sci U S A. 2014 Aug 5; 111(31):E3187-95.
3. Coote P, Leigh KE, Yu TY, Khaneja N, Wagner G, Arthanari H. A new broadband homonuclear mixing pulse for NMR with low applied power. J Chem Phys. 2014 Jul 14; 141(2):024201.
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